Open AccessStructures of the rat complement regulator CrrY
Author(s) -
Roversi Pietro,
Johnson Steven,
Caesar Joseph J. E.,
McLean Florence,
Leath Kirstin J.,
Tsiftsoglou Stefanos A.,
Morgan B. Paul,
Harris Claire L.,
Sim Robert B.,
Lea Susan M.
Publication year - 2011
Publication title -
acta crystallographica section f
Language(s) - English
Resource type - Journals
ISSN - 1744-3091
DOI - 10.1107/s1744309111016551
Subject(s) - regulator , complement (music) , microbiology and biotechnology , complement system , complement control protein , complement receptor , biology , receptor , chemistry , biophysics , immunology , antibody , biochemistry , gene , complementation , phenotype
Complement receptor 1‐related protein Y (CrrY) is an important cell‐surface regulator of complement that is unique to rodent species. The structure of rat CrrY domains 1–4 has been determined in two distinct crystal forms and reveals a 70° bend between domains 3 and 4. Comparisons of this structure with those of other complement regulators suggests that rearrangement of this interface may occur on forming the regulatory complex with C3b.