Open AccessStructure of Plasmodium falciparum ADP‐ribosylation factor 1
Author(s) -
Cook William J.,
Smith Craig D.,
Senkovich Olga,
Holder Anthony A.,
Chattopadhyay Debasish
Publication year - 2010
Publication title -
acta crystallographica section f
Language(s) - English
Resource type - Journals
ISSN - 1744-3091
DOI - 10.1107/s1744309110036997
Subject(s) - adp ribosylation factor , plasmodium falciparum , gtpase , small gtpase , malaria , microbiology and biotechnology , plasmodium (life cycle) , biology , parasite hosting , immunology , signal transduction , endoplasmic reticulum , world wide web , computer science , golgi apparatus
Vesicular trafficking may play a crucial role in the pathogenesis and survival of the malaria parasite. ADP‐ribosylation factors (ARFs) are among the major components of vesicular trafficking pathways in eukaryotes. The crystal structure of ARF1 GTPase from Plasmodium falciparum has been determined in the GDP‐bound conformation at 2.5 Å resolution and is compared with the structures of mammalian ARF1s.