Open AccessStructure of a stacked anthraquinone–DNA complex
Author(s) -
De Luchi Daniela,
Usón Isabel,
Wright Glenford,
Gouyette Catherine,
Subirana Juan A.
Publication year - 2010
Publication title -
acta crystallographica section f
Language(s) - English
Resource type - Journals
ISSN - 1744-3091
DOI - 10.1107/s1744309110030034
Subject(s) - anthraquinone , base pair , crystal structure , crystallography , intercalation (chemistry) , molecule , dna , base (topology) , derivative (finance) , crystal (programming language) , stereochemistry , molecular structure of nucleic acids: a structure for deoxyribose nucleic acid , chemistry , mathematics , organic chemistry , biochemistry , computer science , mathematical analysis , financial economics , programming language , economics
The crystal structure of the telomeric sequence d(U Br AGG) interacting with an anthraquinone derivative has been solved by MAD. In all previously studied complexes of intercalating drugs, the drug is usually sandwiched between two DNA base pairs. Instead, the present structure looks like a crystal of stacked anthraquinone molecules in which isolated base pairs are intercalated. Unusual base pairs are present in the structure, such as G·G and A·U Br reverse Watson–Crick base pairs.