Open AccessNew variants of known folds: do they bring new biology?
Author(s) -
Koonin Eugene V.
Publication year - 2010
Publication title -
acta crystallographica section f
Language(s) - English
Resource type - Journals
ISSN - 1744-3091
DOI - 10.1107/s1744309110013242
Subject(s) - computational biology , context (archaeology) , sequence (biology) , biology , characterization (materials science) , evolutionary biology , function (biology) , genetics , nanotechnology , paleontology , materials science
New distinct versions of known protein folds provide a powerful means of protein‐function prediction that complements sequence and genomic context analysis. These structures do not supplant direct biochemical experiments, but are indispensable for the complete characterization of proteins.