X‐ray structure of the NO‐bound Cu B  in bovine cytochrome  c  oxidase | Zendy

Ohta Kazuhiro | Zendy; Muramoto Kazumasa | Zendy; ShinzawaItoh Kyoko | Zendy; Yamashita Eiki | Zendy; Yoshikawa Shinya | Zendy; Tsukihara Tomitake | Zendy

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X‐ray structure of the NO‐bound Cu B in bovine cytochrome c oxidase

Author(s) -

Ohta Kazuhiro,

Muramoto Kazumasa,

ShinzawaItoh Kyoko,

Yamashita Eiki,

Yoshikawa Shinya,

Tsukihara Tomitake

Publication year - 2010

Publication title -

acta crystallographica section f

Language(s) - English

Resource type - Journals

ISSN - 1744-3091

DOI - 10.1107/s1744309109055109

Subject(s) - cytochrome c oxidase , crystallography , chemistry , electron transport complex iv , nitric oxide , molecule , oxidase test , oxygen , heme a , cytochrome , stereochemistry , enzyme , biochemistry , organic chemistry

The X‐ray crystallographic structure of nitric oxide‐treated bovine heart cytochrome c oxidase (CcO) in the fully reduced state has been determined at 50 K under light illumination. In this structure, nitric oxide (NO) is bound to the CcO oxygen‐reduction site, which consists of haem and a Cu atom (the haem a 3 –Cu B site). Electron density for the NO molecule was observed close to Cu B . The refined structure indicates that NO is bound to Cu B in a side‐on manner.

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