Crystallization and preliminary crystallographic analysis of the measles virus hemagglutinin in complex with the CD46 receptor

The measles virus (MV) hemagglutinin (MV‐H) mediates the attachment of MV particles to cell‐surface receptors for entry into host cells. MV uses two receptors for attachment to host cells: the complement‐control protein CD46 and the signalling lymphocyte activation molecule (SLAM). The MV‐H glycoprotein from an Edmonston MV variant and the MV‐binding fragment of the CD46 receptor were overproduced in mammalian cells and used to crystallize an MV‐H–CD46 complex. Well diffracting crystals containing two complexes in the asymmetric unit were obtained and the structure of the complex was solved by the molecular‐replacement method.