Open AccessThe structure of BVU2987 from Bacteroides vulgatus reveals a superfamily of bacterial periplasmic proteins with possible inhibitory function
Author(s) -
Das Debanu,
Finn Robert D.,
Carlton Dennis,
Miller Mitchell D.,
Abdubek Polat,
Astakhova Tamara,
Axelrod Herbert L.,
Bakolitsa Constantina,
Chen Connie,
Chiu HsiuJu,
Chiu Michelle,
Clayton Thomas,
Deller Marc C.,
Duan Lian,
Ellrott Kyle,
Ernst Dustin,
Farr Carol L.,
Feuerhelm Julie,
Grant Joanna C.,
Grzechnik Anna,
Han Gye Won,
Jaroszewski Lukasz,
Jin Kevin K.,
Klock Heath E.,
Knuth Mark W.,
Kozbial Piotr,
Krishna S. Sri,
Kumar Abhinav,
Marciano David,
McMullan Daniel,
Morse Andrew T.,
Nigoghossian Edward,
Nopakun Amanda,
Okach Linda,
Puckett Christina,
Reyes Ron,
Rife Christopher L.,
Sefcovic Natasha,
Tien Henry J.,
Trame Christine B.,
Van Den Bedem Henry,
Weekes Dana,
Wooten Tiffany,
Xu Qingping,
Hodgson Keith O.,
Wooley John,
Elsliger MarcAndré,
Deacon Ashley M.,
Godzik Adam,
Lesley Scott A.,
Wilson Ian A.
Publication year - 2010
Publication title -
acta crystallographica section f
Language(s) - English
Resource type - Journals
ISSN - 1744-3091
DOI - 10.1107/s1744309109046788
Subject(s) - periplasmic space , biology , function (biology) , protein structure , bacteroides , peptide sequence , bacteroides fragilis , protein family , biochemistry , computational biology , microbiology and biotechnology , chemistry , genetics , bacteria , gene , escherichia coli
Proteins that contain the DUF2874 domain constitute a new Pfam family PF11396. Members of this family have predominantly been identified in microbes found in the human gut and oral cavity. The crystal structure of one member of this family, BVU2987 from Bacteroides vulgatus , has been determined, revealing a β‐lactamase inhibitor protein‐like structure with a tandem repeat of domains. Sequence analysis and structural comparisons reveal that BVU2987 and other DUF2874 proteins are related to β‐lactamase inhibitor protein, PepSY and SmpA_OmlA proteins and hence are likely to function as inhibitory proteins.