Open AccessPreliminary crystallographic analysis of mouse Elf3 C‐terminal DNA‐binding domain in complex with type II TGF‐β receptor promoter DNA
Author(s) -
Agarkar Vinod B.,
Babayeva Nigar D.,
Rizzino Angie,
Tahirov Tahir H.
Publication year - 2009
Publication title -
acta crystallographica section f
Language(s) - English
Resource type - Journals
ISSN - 1744-3091
DOI - 10.1107/s1744309109038007
Subject(s) - dna , dna binding domain , biology , microbiology and biotechnology , transcription factor , hmg box , recombinant dna , gene , transforming growth factor , promoter , transcription (linguistics) , dna binding site , dna binding protein , genetics , gene expression , philosophy , linguistics
Ets proteins are transcription factors that activate or repress the expression of genes that are involved in various biological processes, including cellular proliferation, differentiation, development, transformation and apoptosis. Like other Ets‐family members, Elf3 functions as a sequence‐specific DNA‐binding transcriptional factor. A mouse Elf3 C‐terminal fragment (amino‐acid residues 269–371) containing the DNA‐binding domain has been crystallized in complex with mouse type II TGF‐β receptor promoter (TβR‐II) DNA. The crystals belonged to space group P 2 1 2 1 2 1 , with unit‐cell parameters a = 42.66, b = 52, c = 99.78 Å, and diffracted to a resolution of 2.2 Å.
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