Open AccessThe production and crystallization of the human leukocyte antigen class II molecules HLA‐DQ2 and HLA‐DQ8 complexed with deamidated gliadin peptides implicated in coeliac disease
Author(s) -
Henderson Kate N.,
Reid Hugh H.,
Borg Natalie A.,
Broughton Sophie E.,
Huyton Trevor,
Anderson Robert P.,
McCluskey James,
Rossjohn Jamie
Publication year - 2007
Publication title -
acta crystallographica section f
Language(s) - English
Resource type - Journals
ISSN - 1744-3091
DOI - 10.1107/s1744309107051408
Subject(s) - human leukocyte antigen , gliadin , coeliac disease , major histocompatibility complex , gluten , immunology , chemistry , antigen , mhc class ii , biology , disease , biochemistry , medicine , pathology
The major histocompatibility complex (MHC) class II molecules HLA‐DQ2 and HLA‐DQ8 are key risk factors in coeliac disease, as they bind deamidated gluten peptides that are subsequently recognized by CD4 + T cells. Here, the production and crystallization of both HLA‐DQ2 and HLA‐DQ8 in complex with the deamidated gliadin peptides DQ2 α‐I (PQPELPYPQ) and DQ8 α‐I (EGSFQPSQE), respectively, are reported.