Open AccessHexammineruthenium(III) ion interactions with Z‐DNA
Author(s) -
Bharanidharan D.,
Thiyagarajan S.,
Gautham N.
Publication year - 2007
Publication title -
acta crystallographica section f
Language(s) - English
Resource type - Journals
ISSN - 1744-3091
DOI - 10.1107/s1744309107047781
Subject(s) - random hexamer , orthorhombic crystal system , tautomer , base pair , duplex (building) , crystallography , ion , chemistry , nucleobase , resolution (logic) , dna , metal , metal ions in aqueous solution , stereochemistry , crystal structure , biochemistry , computer science , organic chemistry , artificial intelligence
The hexamer duplex d(CGCGCA)·d(TGCGCG) was crystallized with hexammineruthenium(III) ions in an orthorhombic space group; the crystals diffracted to 1.54 Å resolution. Strong ion interactions with the adenine base induce a tautomeric shift from the amino to the imino form. Consequently, the A·T base pairing is disrupted. This structural study may be relevant to metal toxicity.