Open AccessStructure of the conserved hypothetical protein MAL13P1.257 from Plasmodium falciparum
Author(s) -
Holmes Margaret A.,
Buckner Frederick S.,
Van Voorhis Wesley C.,
Mehlin Christopher,
Boni Erica,
Earnest Thomas N.,
DeTitta George,
Luft Joseph,
Lauricella Angela,
Anderson Lori,
Kalyuzhniy Oleksandr,
Zucker Frank,
Schoenfeld Lori W.,
Hol Wim G. J.,
Merritt Ethan A.
Publication year - 2006
Publication title -
acta crystallographica section f
Language(s) - English
Resource type - Journals
ISSN - 1744-3091
DOI - 10.1107/s1744309106005847
Subject(s) - plasmodium falciparum , biology , computational biology , virology , malaria , immunology
The structure of a conserved hypothetical protein, PlasmoDB sequence MAL13P1.257 from Plasmodium falciparum , Pfam sequence family PF05907, has been determined as part of the structural genomics effort of the Structural Genomics of Pathogenic Protozoa consortium. The structure was determined by multiple‐wavelength anomalous dispersion at 2.17 Å resolution. The structure is almost entirely β‐sheet; it consists of 15 β‐strands and one short 3 10 ‐helix and represents a new protein fold. The packing of the two monomers in the asymmetric unit indicates that the biological unit may be a dimer.