Open Access3D printed devices and infrastructure for liquid sample delivery at the European XFEL
Author(s) -
Vakili Mohammad,
Bielecki Johan,
Knoška Juraj,
Otte Florian,
Han Huijong,
Kloos Marco,
Schubert Robin,
Delmas Elisa,
Mills Grant,
de Wijn Raphael,
Letrun Romain,
Dold Simon,
Bean Richard,
Round Adam,
Kim Yoonhee,
Lima Frederico A.,
Dörner Katerina,
Valerio Joana,
Heymann Michael,
Mancuso Adrian P.,
Schulz Joachim
Publication year - 2022
Publication title -
journal of synchrotron radiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 99
ISSN - 1600-5775
DOI - 10.1107/s1600577521013370
Subject(s) - femtosecond , sample (material) , materials science , laser , 3d printing , characterization (materials science) , nanotechnology , optics , chemistry , chromatography , physics , composite material
The Sample Environment and Characterization (SEC) group of the European X‐ray Free‐Electron Laser (EuXFEL) develops sample delivery systems for the various scientific instruments, including systems for the injection of liquid samples that enable serial femtosecond X‐ray crystallography (SFX) and single‐particle imaging (SPI) experiments, among others. For rapid prototyping of various device types and materials, sub‐micrometre precision 3D printers are used to address the specific experimental conditions of SFX and SPI by providing a large number of devices with reliable performance. This work presents the current pool of 3D printed liquid sample delivery devices, based on the two‐photon polymerization (2PP) technique. These devices encompass gas dynamic virtual nozzles (GDVNs), mixing‐GDVNs, high‐viscosity extruders (HVEs) and electrospray conical capillary tips (CCTs) with highly reproducible geometric features that are suitable for time‐resolved SFX and SPI experiments at XFEL facilities. Liquid sample injection setups and infrastructure on the Single Particles, Clusters, and Biomolecules and Serial Femtosecond Crystallography (SPB/SFX) instrument are described, this being the instrument which is designated for biological structure determination at the EuXFEL.