Hydrochlorothiazide  N , N ‐dimethylacetamide disolvate | Zendy

Johnston Andrea | Zendy; Kennedy Alan R. | Zendy; Florence Alastair J. | Zendy

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Hydrochlorothiazide N , N ‐dimethylacetamide disolvate

Author(s) -

Johnston Andrea,

Kennedy Alan R.,

Florence Alastair J.

Publication year - 2006

Publication title -

acta crystallographica section e

Language(s) - English

Resource type - Journals

ISSN - 1600-5368

DOI - 10.1107/s1600536806022859

Subject(s) - dimethylacetamide , hydrochlorothiazide , chemistry , benzothiadiazine , solvent , medicinal chemistry , molecule , sulfonamide , hydrogen bond , stereochemistry , organic chemistry , medicine , blood pressure

Hydrochlorothiazide forms a 1:2 solvate with N , N ‐dimethylacetamide (systematic name: 6‐chloro‐3,4‐dihydro‐2 H ‐1,2,4‐benzothiadiazine‐7‐sulfonamide 1,1‐dioxide dimethylacetamide disolvate), C 7 H 8 ClN 3 O 4 S 2 ·2C 4 H 9 NO. The compound crystallizes with one hydrochorothiazide and two disordered solvent molecules in the asymmetric unit, with a hydrogen‐bonding network comprising four N—H⋯O contacts.

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