Open AccessHydrochlorothiazide N , N ‐dimethylacetamide disolvate
Author(s) -
Johnston Andrea,
Kennedy Alan R.,
Florence Alastair J.
Publication year - 2006
Publication title -
acta crystallographica section e
Language(s) - English
Resource type - Journals
ISSN - 1600-5368
DOI - 10.1107/s1600536806022859
Subject(s) - dimethylacetamide , hydrochlorothiazide , chemistry , benzothiadiazine , solvent , medicinal chemistry , molecule , sulfonamide , hydrogen bond , stereochemistry , organic chemistry , medicine , blood pressure
Hydrochlorothiazide forms a 1:2 solvate with N , N ‐dimethylacetamide (systematic name: 6‐chloro‐3,4‐dihydro‐2 H ‐1,2,4‐benzothiadiazine‐7‐sulfonamide 1,1‐dioxide dimethylacetamide disolvate), C 7 H 8 ClN 3 O 4 S 2 ·2C 4 H 9 NO. The compound crystallizes with one hydrochorothiazide and two disordered solvent molecules in the asymmetric unit, with a hydrogen‐bonding network comprising four N—H⋯O contacts.