Open AccessHydrochlorothiazide N , N ‐dimethylformamide solvate
Author(s) -
Johnston Andrea,
Kennedy Alan R.,
Florence Alastair J.
Publication year - 2006
Publication title -
acta crystallographica section e
Language(s) - English
Resource type - Journals
ISSN - 1600-5368
DOI - 10.1107/s1600536806011391
Subject(s) - hydrochlorothiazide , dimethylformamide , benzothiadiazine , chemistry , solvent , molecule , sulfonamide , hydrogen bond , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry , endocrinology , medicine , blood pressure
Hydrochlorothiazide forms a 1:1 solvate with N , N ‐dimethylformamide (systematic name: 6‐chloro‐3,4‐dihydro‐2 H ‐1,2,4‐benzothiadiazine‐7‐sulfonamide‐1,1‐dioxide dimethylformamide solvate), C 7 H 8 ClN 3 O 4 S 2 ·C 3 H 7 NO. The compound crystallizes with two molecules of hydrochlorothiazide and two solvent molecules in the asymmetric unit and displays an extensive hydrogen‐bonding network.