Open AccessAmpicillin trihydrate from synchrotron powder diffraction data
Author(s) -
Burley Jonathan C.,
Streek Jacco van de,
Stephens Peter W.
Publication year - 2006
Publication title -
acta crystallographica section e
Language(s) - English
Resource type - Journals
ISSN - 1600-5368
DOI - 10.1107/s1600536806001371
Subject(s) - ampicillin , molecule , hydrogen bond , crystal structure , crystallography , synchrotron , x ray crystallography , chemistry , powder diffraction , penicillin , diffraction , crystal (programming language) , lactam , stereochemistry , antibiotics , organic chemistry , physics , optics , biochemistry , programming language , computer science
The crystal structure of ampicillin trihydrate {systematic name: 6‐[ d (−)‐α‐aminophenylacetamido]penicillanic acid trihydrate}, C 16 H 19 N 3 O 4 S·3H 2 O, a broad‐spectrum β‐lactam antibiotic of the aminopenicillin type, has been determined from synchrotron X‐ray powder diffraction data. The three water molecules form an infinite hydrogen‐bonded chain through the crystal structure, with hydrogen bonds to the NH 3 + , COO − , C=O and NH groups of the ampicillin molecules.