Hydrochlorothiazide–1,4‐dioxane (1/1) | Zendy

Johnston Andrea | Zendy; Florence Alastair J. | Zendy; Kennedy Alan R. | Zendy

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Hydrochlorothiazide–1,4‐dioxane (1/1)

Author(s) -

Johnston Andrea,

Florence Alastair J.,

Kennedy Alan R.

Publication year - 2005

Publication title -

acta crystallographica section e

Language(s) - English

Resource type - Journals

ISSN - 1600-5368

DOI - 10.1107/s1600536805022464

Subject(s) - diazine , hydrogen bond , chemistry , hydrochlorothiazide , medicinal chemistry , sulfonamide , solvent , bioinformatics , stereochemistry , molecule , organic chemistry , medicine , biology , blood pressure

Hydrochlorothiazide forms a 1:1 solvate with 1,4‐dioxane, C 7 H 8 ClN 3 O 4 S 2 ·C 4 H 8 O 2 [systematic name: 6‐chloro‐3,4‐dihydro‐2 H ‐1,2,4‐benzothiadiazine‐7‐sulfonamide 1,1‐dioxide–1,4‐dioxane ()]. The asymmetric unit comprises one molecule of hydrochlorothiazide and halves of two solvent molecules arranged around inversion centres. The structure contains a hydrogen‐bonding network comprising three N—H⋯O and one N—H⋯N hydrogen bonds.

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