Open AccessHydrochlorothiazide–1,4‐dioxane (1/1)
Author(s) -
Johnston Andrea,
Florence Alastair J.,
Kennedy Alan R.
Publication year - 2005
Publication title -
acta crystallographica section e
Language(s) - English
Resource type - Journals
ISSN - 1600-5368
DOI - 10.1107/s1600536805022464
Subject(s) - diazine , hydrogen bond , chemistry , hydrochlorothiazide , medicinal chemistry , sulfonamide , solvent , bioinformatics , stereochemistry , molecule , organic chemistry , medicine , biology , blood pressure
Hydrochlorothiazide forms a 1:1 solvate with 1,4‐dioxane, C 7 H 8 ClN 3 O 4 S 2 ·C 4 H 8 O 2 [systematic name: 6‐chloro‐3,4‐dihydro‐2 H ‐1,2,4‐benzothiadiazine‐7‐sulfonamide 1,1‐dioxide–1,4‐dioxane ()]. The asymmetric unit comprises one molecule of hydrochlorothiazide and halves of two solvent molecules arranged around inversion centres. The structure contains a hydrogen‐bonding network comprising three N—H⋯O and one N—H⋯N hydrogen bonds.