Sildenafil citrate monohydrate | Zendy

Yathirajan Hemmige S. | Zendy; Nagaraj Basavegowda | Zendy; Nagaraja Padmarajaiah | Zendy; Bolte Michael | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Sildenafil citrate monohydrate

Author(s) -

Yathirajan Hemmige S.,

Nagaraj Basavegowda,

Nagaraja Padmarajaiah,

Bolte Michael

Publication year - 2005

Publication title -

acta crystallographica section e

Language(s) - English

Resource type - Journals

ISSN - 1600-5368

DOI - 10.1107/s1600536805002564

Subject(s) - ring (chemistry) , alkoxy group , hydrogen bond , chemistry , protonation , sildenafil , piperazine , intramolecular force , medicinal chemistry , sulfonyl , benzene , stereochemistry , ion , molecule , organic chemistry , alkyl , medicine

Sildenafil citrate is well known as Viagra for the treatment of erectile dysfuncion. In the title compound (systematic name: 1‐{[3‐(6,7‐Dihydro‐1‐methyl‐7‐oxo‐3‐propyl‐1 H ‐pyrazolo[4,3‐ d ]pyrimidin‐5‐yl)‐4‐ethoxyphenyl]sulfonyl}‐4‐methylpiperazinium citrate monohydrate), C 22 H 31 N 6 O 4 S + ·C 6 H 7 O 7 − ·H 2 O, the pyrazolopyrimidone ring system and the benzene ring are almost coplanar, enabling an intramolecular hydrogen bond between the pyrazolopyrimidone NH group and the O atom of the ethoxy group. One of the N atoms of the piperazine ring is protonated and the citrate molecule exists as an anion. The crystal packing is stabilized by several hydrogen bonds.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research