Open AccessSCOP, Structural Classification of Proteins Database: Applications to Evaluation of the Effectiveness of Sequence Alignment Methods and Statistics of Protein Structural Data
Author(s) -
Hubbard Tim J. P.,
Ailey Bart,
Brenner Steven E.,
Murzin Alexey G.,
Chothia Cyrus
Publication year - 1998
Publication title -
acta crystallographica section d
Language(s) - English
Resource type - Journals
ISSN - 1399-0047
DOI - 10.1107/s0907444998009172
Subject(s) - structural classification of proteins database , database , protein structure database , protein data bank , computer science , sequence (biology) , feature (linguistics) , protein evolution , population , information retrieval , data mining , protein structure , sequence database , biology , genetics , philosophy , biochemistry , linguistics , demography , sociology , gene
The Structural Classification of Proteins (SCOP) database provides a detailed and comprehensive description of the relationships of all known protein structures. The classification is on hierarchical levels: the first two levels, family and superfamily, describe near and far evolutionary relationships; the third, fold, describes geometrical relationships. The distinction between evolutionary relationships and those that arise from the physics and chemistry of proteins is a feature that is unique to this database, so far. The database can be used as a source of data to calibrate sequence search algorithms and for the generation of population statistics on protein structures. The database and its associated files are freely accessible from a number of WWW sites mirrored from URL http://scop. mrc-lmb.cam.ac.uk/scop/.