Open AccessProtein Sequence Alignment Techniques
Author(s) -
Barton Geoffrey J.
Publication year - 1998
Publication title -
acta crystallographica section d
Language(s) - English
Resource type - Journals
ISSN - 1399-0047
DOI - 10.1107/s0907444998008324
Subject(s) - multiple sequence alignment , structural alignment , alignment free sequence analysis , sequence alignment , sequence (biology) , computational biology , smith–waterman algorithm , sequence analysis , sequence logo , computer science , consensus sequence , protein structure , genetics , algorithm , biology , base sequence , peptide sequence , gene , biochemistry
The basic algorithms for alignment of two or more protein sequences are explained. Alternative methods for scoring substitutions and gaps (insertions and deletions) are described, as are global and local alignment methods. Multiple alignment techniques are explained, including methods for profile comparison. A summary is given of programs for the alignment and analysis of protein sequences, either from sequence alone, or from three‐dimensional structure.