Open AccessMAD phasing: Bayesian estimates of F A
Author(s) -
Terwilliger T. C.
Publication year - 1994
Publication title -
acta crystallographica section d
Language(s) - English
Resource type - Journals
ISSN - 1399-0047
DOI - 10.1107/s0907444993008224
Subject(s) - bayesian probability , phaser , statistics , computer science , econometrics , algorithm , mathematics , physics , optics
A Bayesian approach is applied to the calculation of Patterson functions and cross‐Fourier maps in the analysis of multi‐wavelength anomalous‐diffraction (MAD) data. This procedure explicitly incorporates information available a priori on the likely magnitudes of partial structure factors ( F A ) corresponding to the anomalously scattering atoms, uses weighted‐average estimates of F A , and incorporates estimates of errors in the data that are not represented in the instrumental uncertainties. The method is demonstrated by application to MAD data collected on selenomethionine‐containing gene V protein.