Open AccessLigSearch : a knowledge‐based web server to identify likely ligands for a protein target
Author(s) -
de Beer Tjaart A. P.,
Laskowski Roman A.,
Duban MarkEugene,
Chan A. W. Edith,
Anderson Wayne F.,
Thornton Janet M.
Publication year - 2013
Publication title -
acta crystallographica section d
Language(s) - English
Resource type - Journals
ISSN - 1399-0047
DOI - 10.1107/s0907444913022294
Subject(s) - web server , computer science , variety (cybernetics) , sequence (biology) , world wide web , computational biology , biology , the internet , biochemistry , artificial intelligence
Identifying which ligands might bind to a protein before crystallization trials could provide a significant saving in time and resources. LigSearch, a web server aimed at predicting ligands that might bind to and stabilize a given protein, has been developed. Using a protein sequence and/or structure, the system searches against a variety of databases, combining available knowledge, and provides a clustered and ranked output of possible ligands. LigSearch can be accessed at http://www.ebi.ac.uk/thornton-srv/databases/LigSearch.