Open AccessEmerging from pseudo‐symmetry: the redetermination of human carbonic anhydrase II in monoclinic P 2 1 with a doubled a axis
Author(s) -
Robbins Arthur H.,
Domsic John F.,
AgbandjeMcKenna Mavis,
McKenna Robert
Publication year - 2010
Publication title -
acta crystallographica section d
Language(s) - English
Resource type - Journals
ISSN - 1399-0047
DOI - 10.1107/s0907444910023723
Subject(s) - monoclinic crystal system , crystallography , carbonic anhydrase , symmetry (geometry) , physics , chemistry , crystal structure , enzyme , nuclear magnetic resonance , mathematics , geometry
The crystal structure of human carbonic anhydrase II in the monoclinic P 2 1 space group with a doubled a axis from that of the usually observed unit cell has recently been reported, with one of the two molecules in the asymmetric unit demonstrating rotational disorder [Robbins et al. (2010), Acta Cryst . D 66 , 628–634]. The structure has been redetermined, with the coordinates of both pseudo‐symmetrically related molecules in the crystallographic asymmetric unit translated by x ′ = x ± 1/4, and no rotational disorder is observed. This corresponds to a different choice of how the four molecules in the unit cell should be grouped into pairs that represent a single asymmetric unit.