A magic triangle for experimental phasing of macromolecules | Zendy

Beck Tobias | Zendy; Krasauskas Andrius | Zendy; Gruene Tim | Zendy; Sheldrick George M. | Zendy

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A magic triangle for experimental phasing of macromolecules

Author(s) -

Beck Tobias,

Krasauskas Andrius,

Gruene Tim,

Sheldrick George M.

Publication year - 2008

Publication title -

acta crystallographica section d

Language(s) - English

Resource type - Journals

ISSN - 1399-0047

DOI - 10.1107/s0907444908030266

Subject(s) - equilateral triangle , macromolecule , phaser , crystallography , chemistry , chemical physics , molecular physics , physics , optics , geometry , mathematics , biochemistry

Obtaining phase information for the solution of macromolecular structures is still one of the bottlenecks in X‐ray crystallography. 5‐Amino‐2,4,6‐triiodoisophthalic acid (I3C), in which three covalently bound iodines form an equilateral triangle, was incorporated into proteins in order to obtain phases by single‐wavelength anomalous dispersion (SAD). An improved binding capability compared with simple heavy‐metal ions, ready availability, improved recognition of potential heavy‐atom sites and low toxicity make I3C particularly suitable for experimental phasing.

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