Open AccessCombining X‐ray and electron‐microscopy data to solve crystal structures
Author(s) -
Navaza Jorge
Publication year - 2008
Publication title -
acta crystallographica section d
Language(s) - English
Resource type - Journals
ISSN - 1399-0047
DOI - 10.1107/s0907444907053334
Subject(s) - electron microscope , resolution (logic) , molecular replacement , x ray , microscopy , monomer , low resolution , cryo electron microscopy , chemistry , materials science , crystallography , nanotechnology , biophysics , computer science , crystal structure , high resolution , physics , optics , biology , artificial intelligence , geology , polymer , remote sensing , organic chemistry
Low‐resolution electron‐microscopy reconstructions can be used as search models in molecular replacement or may be combined with existing monomeric structures in order to produce multimeric models suitable for molecular replacement. The technique is described in the case of viral and subviral particles as well as in the case of oligomeric proteins.