Open AccessSPINE high‐throughput crystallization, crystal imaging and recognition techniques: current state, performance analysis, new technologies and future aspects
Author(s) -
Berry Ian M.,
Dym O.,
Esnouf R. M.,
Harlos K.,
Meged R.,
Perrakis A.,
Sussman J. L.,
Walter T. S.,
Wilson J.,
Messerschmidt Albrecht
Publication year - 2006
Publication title -
acta crystallographica section d
Language(s) - English
Resource type - Journals
ISSN - 1399-0047
DOI - 10.1107/s090744490602943x
Subject(s) - throughput , protein crystallization , spine (molecular biology) , crystallization , computer science , data science , nanotechnology , engineering , bioinformatics , materials science , telecommunications , biology , chemical engineering , wireless
This paper reviews the developments in high‐throughput and nanolitre‐scale protein crystallography technologies within the remit of workpackage 4 of the Structural Proteomics In Europe (SPINE) project since the project's inception in October 2002. By surveying the uptake, use and experience of new technologies by SPINE partners across Europe, a picture emerges of highly successful adoption of novel working methods revolutionizing this area of structural biology. Finally, a forward view is taken of how crystallization methodologies may develop in the future.