Crystallization and preliminary X‐ray analysis of the antimalarial and cytotoxic alkaloid cryptolepine complexed with the DNA fragment d(CCTAGG) 2
Author(s) -
Lisgarten J. N.,
Pous J.,
Coll M.,
Wright C. W.,
Aymami J.
Publication year - 2002
Publication title -
acta crystallographica section d
Language(s) - English
Resource type - Journals
ISSN - 1399-0047
DOI - 10.1107/s0907444901018960
Subject(s) - alkaloid , crystallization , ammonium sulfate , stereochemistry , chemistry , dna , crystallography , organic chemistry , biochemistry
Crystals of the indoloquinoline alkaloid cryptolepine complexed with the DNA fragment d(CCTAGG) 2 have been grown by the hanging‐drop technique at 293 K using ammonium sulfate as the precipitating agent. Over a period of three weeks, yellow tapering bullet‐shaped crystals grew to maximum dimensions of 0.2 × 0.1 × 0.1 mm. The crystals belong to space group P 6 4 , with unit‐cell parameters a = b = 29.960, c = 39.64 Å, α = β = 90, γ = 120°, and diffract to 1.4 Å.
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