Open AccessStructure and intermolecular interactions of glipizide from laboratory X‐ray powder diffraction
Author(s) -
Burley Jonathan C.
Publication year - 2005
Publication title -
acta crystallographica section b
Language(s) - English
Resource type - Journals
eISSN - 1600-5740
pISSN - 0108-7681
DOI - 10.1107/s0108768105025991
Subject(s) - glipizide , powder diffraction , crystallography , intermolecular force , x ray , materials science , chemistry , organic chemistry , physics , optics , molecule , medicine , insulin
The crystal structure of glipizide, used as a major treatment of type‐2 diabetes, has been determined ab initio using variable‐temperature laboratory X‐ray powder diffraction combined with a direct‐space Monte Carlo/simulated annealing methodology. The strengths of the intermolecular interactions (van der Waals, π–π stacking, hydrogen bonding and steric interlock) were quantitatively estimated using the thermal expansion data, which were collected in the same set of experiments as those used to determine the structure.