Open Access( R )‐4‐(4‐Aminophenyl)‐2,2,4‐trimethylchroman and ( S )‐4‐(4‐aminophenyl)‐2,2,4‐trimethylthiachroman
Author(s) -
Frampton Christopher S.,
MacNicol David D.,
Wilson Derek R.
Publication year - 2011
Publication title -
acta crystallographica section c
Language(s) - English
Resource type - Journals
eISSN - 1600-5759
pISSN - 0108-2701
DOI - 10.1107/s0108270111012157
Subject(s) - isostructural , absolute configuration , hydrogen bond , dispersion (optics) , stereochemistry , enantiomer , crystallography , chemistry , materials science , crystal structure , physics , molecule , organic chemistry , optics
The title compounds, C 18 H 21 NO and C 18 H 21 NS, in their enantiomerically pure forms are isostructural with the enantiomerically pure 4‐(4‐hydroxyphenyl)‐2,2,4‐trimethylchroman and 4‐(2,4‐dihydroxyphenyl)‐2,2,4‐trimethylchroman analogues and form extended linear chains via N—H...O or N—H...S hydrogen bonding along the [100] direction. The absolute configuration for both compounds was determined by anomalous dispersion methods with reference to both the Flack parameter and, for the light‐atom compound, Bayesian statistics on Bijvoet differences.