Open AccessTwo isomeric 10‐methyl‐8‐phenyl‐11‐pyridyl‐6,8‐dihydro‐5 H ‐benzo[ f ]pyrazolo[3,4‐ b ]quinolines: cyclic hydrogen‐bonded tetramers versus isolated molecules
Author(s) -
Portilla Jaime,
Serrano Hugo,
Cobo Justo,
Low John N.,
Glidewell Christopher
Publication year - 2005
Publication title -
acta crystallographica section c
Language(s) - English
Resource type - Journals
eISSN - 1600-5759
pISSN - 0108-2701
DOI - 10.1107/s0108270105021876
Subject(s) - quinoline , chemistry , molecule , hydrogen bond , enantiomer , stereochemistry , methyl group , medicinal chemistry , group (periodic table) , crystallography , organic chemistry
The molecules of 10‐methyl‐8‐phenyl‐11‐(3‐pyridyl)‐6,8‐dihydro‐5 H ‐benzo[ f ]pyrazolo[3,4‐ b ]quinoline, C 26 H 20 N 4 , (I), are linked by a single C—H⋯N hydrogen bond into cyclic R (12) tetramers generated by a axis. In isomeric 10‐methyl‐8‐phenyl‐11‐(4‐pyridyl)‐6,8‐dihydro‐5 H ‐benzo[ f ]pyrazolo[3,4‐ b ]quinoline, (II), which crystallizes with Z ′ = 2 in space group P 2 1 2 1 2, the two independent molecules are nearly enantiomeric but there are no direction‐specific interactions between them.