Close Encounters of the ARF Kind: Proximity-Based ARF1 GTPase Activity Regulates Vesicle Trafficking
Author(s) -
Philip Carella
Publication year - 2020
Publication title -
the plant cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.324
H-Index - 341
eISSN - 1532-298X
pISSN - 1040-4651
DOI - 10.1105/tpc.20.00469
Subject(s) - vesicle , guanine nucleotide exchange factor , adp ribosylation factor , biology , gtpase , microbiology and biotechnology , gtp' , small gtpase , gtpase activating protein , guanine , membrane , g protein , biochemistry , signal transduction , nucleotide , golgi apparatus , endoplasmic reticulum , enzyme , gene
ADP-RIBOSYLATION FACTOR (ARF) proteins play essential roles in vesicle trafficking by regulating the formation of membrane vesicles that move cargo throughout the cell. Their activity is controlled by specific guanine exchange factors (ARF-GEFs) that activate ARFs by catalyzing a GDP-to -GTP
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