The Arabidopsis SUMO E3 Ligase AtMMS21 Dissociates the E2Fa/DPa Complex in Cell Cycle Regulation | Zendy

Yiyang Liu | Zendy; Jianbin Lai | Zendy; Mengyuan Yu | Zendy; Feige Wang | Zendy; Juanjuan Zhang | Zendy; Jieming Jiang | Zendy; Huan Hu | Zendy; Qian Wu | Zendy; GuoHui Lu | Zendy; Panglian Xu | Zendy; Chengwei Yang | Zendy

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The Arabidopsis SUMO E3 Ligase AtMMS21 Dissociates the E2Fa/DPa Complex in Cell Cycle Regulation

Author(s) -

Yiyang Liu,

Jianbin Lai,

Mengyuan Yu,

Feige Wang,

Juanjuan Zhang,

Jieming Jiang,

Huan Hu,

Qian Wu,

GuoHui Lu,

Panglian Xu,

Chengwei Yang

Publication year - 2016

Publication title -

the plant cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.324

H-Index - 341

eISSN - 1532-298X

pISSN - 1040-4651

DOI - 10.1105/tpc.16.00439

Subject(s) - biology , arabidopsis , ubiquitin ligase , microbiology and biotechnology , dna ligase , genetics , ubiquitin , gene , mutant

Development requires the proper execution and regulation of the cell cycle via precise, conserved mechanisms. Critically, the E2F/DP complex controls the expression of essential genes during cell cycle transitions. Here, we discovered the molecular function of the Arabidopsis thaliana SUMO E3 ligase METHYL METHANESULFONATE SENSITIVITY GENE21 (AtMMS21) in regulating the cell cycle via the E2Fa/DPa pathway. DPa was identified as an AtMMS21-interacting protein and AtMMS21 competes with E2Fa for interaction with DPa. Moreover, DPa is a substrate for SUMOylation mediated by AtMMS21, and this SUMOylation enhances the dissociation of the E2Fa/DPa complex. AtMMS21 also affects the subcellular localization of E2Fa/DPa. The E2Fa/DPa target genes are upregulated in the root of mms21-1 and mms21-1 mutants showed increased endoreplication. Overexpression of DPa affected the root development of mms21-1 , and overexpression of AtMMS21 completely recovered the abnormal phenotypes of 35S:E2Fa-DPa plants. Our results suggest that AtMMS21 dissociates the E2Fa/DPa complex via competition and SUMOylation in the regulation of plant cell cycle.

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