Altered Nuclear Distribution of Recombination Protein RAD51 in Maize Mutants Suggests the Involvement of RAD51 in Meiotic Homology Recognition | Zendy

Wojciech P. Pawlowski | Zendy; Inna Golubovskaya | Zendy; W. Zacheus Cande | Zendy

Open Access

Altered Nuclear Distribution of Recombination Protein RAD51 in Maize Mutants Suggests the Involvement of RAD51 in Meiotic Homology Recognition

Author(s) -

Wojciech P. Pawlowski,

Inna Golubovskaya,

W. Zacheus Cande

Publication year - 2003

Publication title -

the plant cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.324

H-Index - 341

eISSN - 1532-298X

pISSN - 1040-4651

DOI - 10.1105/tpc.012898

Subject(s) - rad51 , meiosis , biology , homologous recombination , mutant , genetics , homology (biology) , recombination , homologous chromosome , synaptonemal complex , genetic recombination , prophase , ectopic recombination , microbiology and biotechnology , gene

The recombination protein RAD51 is a component of the meiotic recombination pathway and has been proposed to play a role in the homology search, a process by which homologous chromosomes find each other before they pair in the prophase of meiosis. To study the relationship between recombination and chromosome pairing, we examined the distribution of RAD51 foci on meiotic chromosomes in maize mutants with defects in chromosome pairing. The patterns of RAD51 distribution showed dramatic variation among the meiotic mutants. The mutants generally exhibited significant decreases in the number of RAD51 foci at zygotene, corresponding to the degree of their pairing defects. These results provide evidence for a key role of RAD51 structures in the homology search.

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