Isolation and Characterization of Swainsonine from Texas Locoweed (Astragalus emoryanus) | Zendy

D. Buscarello H. G. Davis | Zendy; Patrícia Schwarz | Zendy; Tony Hernandez | Zendy; Mike Mitchell | Zendy; Barton H. Warnock | Zendy; A D Elbein | Zendy

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Isolation and Characterization of Swainsonine from Texas Locoweed (Astragalus emoryanus)

Author(s) -

D. Buscarello H. G. Davis,

Patrícia Schwarz,

Tony Hernandez,

Mike Mitchell,

Barton H. Warnock,

A D Elbein

Publication year - 1984

Publication title -

plant physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.554

H-Index - 312

eISSN - 1532-2548

pISSN - 0032-0889

DOI - 10.1104/pp.76.4.972

Subject(s) - swainsonine , astragalus , isolation (microbiology) , biology , botany , microbiology and biotechnology , biochemistry , medicine , alternative medicine , pathology , traditional chinese medicine

Swainsonine (1,2,8-trihydroxyoctahydroindolizine) was isolated from locoweed (Astragalus emoryanus) that grows in Texas. Using a biological assay as a measure of activity and purity, a relatively straightforward purification of the compound is described. The purified material was a potent inhibitor of jack bean alpha-mannosidase and also of glycoprotein processing. The positive ion electron impact mass spectra of this compound was identical to that of authentic swainsonine. Nuclear magnetic resonance analysis also confirmed that the material was swainsonine.

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