Inhibition of Cyanide-Resistant Respiration in Pea Cotyledon Mitochondria by Chloroquine | Zendy

Terrance W. James | Zendy; Mary S. Spencer | Zendy

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Inhibition of Cyanide-Resistant Respiration in Pea Cotyledon Mitochondria by Chloroquine

Author(s) -

Terrance W. James,

Mary S. Spencer

Publication year - 1982

Publication title -

plant physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.554

H-Index - 312

eISSN - 1532-2548

pISSN - 0032-0889

DOI - 10.1104/pp.69.5.1113

Subject(s) - pisum , respiration , cyanide , alternative oxidase , mitochondrion , cotyledon , cytochrome c oxidase , sativum , biochemistry , salicylhydroxamic acid , biology , germination , chemistry , botany , inorganic chemistry

The action on mitochondrial respiration of a ubiquinone analog, chloroquine, has been studied using purified mitochondria from the cotyledons of germinating peas (Pisum sativum L. var. Homesteader). Chloroquine at 3 millimolar did not inhibit malate or succinate oxidation at pH 7.2, but it did inhibit malate (but not succinate) oxidation at pH 8.2. Cyanide-resistant respiration was also inhibited.The implications of these experiments on the role of ubiquinone in the cyanide-resistant respiratory pathway and on the location of the alternate oxidase are discussed.

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