Effects of 3,5-Dihalogenated-4-hydroxybenzonitriles on the Activity of Mitochondria From White Potato Tubers | Zendy

Thomas E. Ferrari | Zendy; Donald E. Moreland | Zendy

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Effects of 3,5-Dihalogenated-4-hydroxybenzonitriles on the Activity of Mitochondria From White Potato Tubers

Author(s) -

Thomas E. Ferrari,

Donald E. Moreland

Publication year - 1969

Publication title -

plant physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.554

H-Index - 312

eISSN - 1532-2548

pISSN - 0032-0889

DOI - 10.1104/pp.44.3.429

Subject(s) - oligomycin , respiration , mitochondrion , oxygen , clark electrode , chemistry , biochemistry , dinitrophenol , atpase , biology , enzyme , botany , organic chemistry , electrode , electrolyte

Effects of the herbicide 3,5-diiodo-4-hydroxybenzonitrile (ioxynil), and its dibromo and dichloro analogs, upon the respiration of mitochondria isolated from white potato tubers (Solanum tuberosum L.) were investigated. Mitochondrial-mediated oxygen uptake was monitored polarographically with a platinum oxygen electrode.With succinate as substrate for mitochondrial oxidation, ioxynil stimulated both ADP-limited and ADP + phosphate-deficient oxygen utilization. Ioxynil also circumvented oligomycin-inhibited respiration and slightly stimulated mitochondrial ATPase activity. Responses produced by ioxynil on respiration were similar to, but occurred at lower concentrations than, those of 2,4-dinitrophenol.The dibromo- and dichloro-substituted analogs of ioxynil also stimulated ADP-limited respiration and released oligomycin-inhibited oxygen uptake. Based on concentration, the decreasing order of uncoupling activity was I > Br > Cl with respect to the halogen substituents.

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