A Kelch domain-containing F-box coding gene negatively regulates flavonoid accumulation in Cucumis melo L. | Zendy

Ari Feder | Zendy; Joseph Burger | Zendy; Shan Gao | Zendy; Efraim Lewinsohn | Zendy; Nurit Katzir | Zendy; Arthur A. Schaffer | Zendy; Ayala Meir | Zendy; Rachel DavidovichRikanati | Zendy; Vitaly Portnoy | Zendy; Amit GalOn | Zendy; Zhangjun Fei | Zendy; Yehezkel Kashi | Zendy; Yaakov Tadmor | Zendy

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A Kelch domain-containing F-box coding gene negatively regulates flavonoid accumulation in Cucumis melo L.

Author(s) -

Ari Feder,

Joseph Burger,

Shan Gao,

Efraim Lewinsohn,

Nurit Katzir,

Arthur A. Schaffer,

Ayala Meir,

Rachel DavidovichRikanati,

Vitaly Portnoy,

Amit GalOn,

Zhangjun Fei,

Yehezkel Kashi,

Yaakov Tadmor

Publication year - 2015

Publication title -

plant physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.554

H-Index - 312

eISSN - 1532-2548

pISSN - 0032-0889

DOI - 10.1104/pp.15.01008

Subject(s) - naringenin , cucumis , flavonoid , phenylpropanoid , flavonoid biosynthesis , biology , chalcone , gene , chalcone synthase , biochemistry , botany , gene expression , chemistry , transcriptome , stereochemistry , biosynthesis , antioxidant

The flavonoids are phenylpropanoid-derived metabolites that are ubiquitous in plants, playing many roles in growth and development. Recently, we observed that fruit rinds of yellow casaba muskmelons (Cucumis melo 'Inodorous Group') accumulate naringenin chalcone, a yellow flavonoid pigment. With RNA-sequencing analysis of bulked segregants representing the tails of a population segregating for naringenin chalcone accumulation followed by fine mapping and genetic transformation, we identified a Kelch domain-containing F-box protein coding (CmKFB) gene that, when expressed, negatively regulates naringenin chalcone accumulation. Additional metabolite analysis indicated that downstream flavonoids are accumulated together with naringenin chalcone, whereas CmKFB expression diverts the biochemical flux toward coumarins and general phenylpropanoids. These results show that CmKFB functions as a posttranscriptional regulator that diverts flavonoid metabolic flux.

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