Open AccessFRIENDLY Regulates Mitochondrial Distribution, Fusion, and Quality Control in Arabidopsis
Author(s) -
Amr M. El Zawily,
Markus Schwarzländer,
Iris Finkemeier,
Iain G. Johnston,
Abdelilah Benamar,
Yang Cao,
C. Gissot,
Andreas J. Meyer,
Ken Wilson,
Raju Datla,
David Macherel,
Nick S. Jones,
David C. Logan
Publication year - 2014
Publication title -
plant physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.554
H-Index - 312
eISSN - 1532-2548
pISSN - 0032-0889
DOI - 10.1104/pp.114.243824
Subject(s) - mitochondrion , mitochondrial fusion , arabidopsis , biology , arabidopsis thaliana , microbiology and biotechnology , phenotype , mitochondrial dna , genetics , gene , mutant
Mitochondria are defining components of most eukaryotes. However, higher plant mitochondria differ biochemically, morphologically, and dynamically from those in other eukaryotes. FRIENDLY, a member of the CLUSTERED MITOCHONDRIA superfamily, is conserved among eukaryotes and is required for correct distribution of mitochondria within the cell. We sought to understand how disruption of FRIENDLY function in Arabidopsis (Arabidopsis thaliana) leads to mitochondrial clustering and the effects of this aberrant chondriome on cell and whole-plant physiology. We present evidence for a role of FRIENDLY in mediating intermitochondrial association, which is a necessary prelude to mitochondrial fusion. We demonstrate that disruption of mitochondrial association, motility, and chondriome structure in friendly affects mitochondrial quality control and leads to mitochondrial stress, cell death, and strong growth phenotypes.
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