Direct Determination of Vibrational Density of States Change on Ligand Binding to a Protein | Zendy

Erika Balog | Zendy; Torsten Becker | Zendy; Martin Oettl | Zendy; R.E. Lechner | Zendy; Roy M. Daniel | Zendy; John Finney | Zendy; Jeremy C. Smith | Zendy

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Direct Determination of Vibrational Density of States Change on Ligand Binding to a Protein

Author(s) -

Erika Balog,

Torsten Becker,

Martin Oettl,

R.E. Lechner,

Roy M. Daniel,

John Finney,

Jeremy C. Smith

Publication year - 2004

Publication title -

physical review letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.688

H-Index - 673

eISSN - 1079-7114

pISSN - 0031-9007

DOI - 10.1103/physrevlett.93.028103

Subject(s) - binding energy , dihydrofolate reductase , ligand (biochemistry) , inelastic scattering , materials science , atomic physics , physics , scattering , chemistry , nuclear magnetic resonance , enzyme , receptor , quantum mechanics , biochemistry

The change in the vibrational density of states of a protein (dihydrofolate reductase) on binding a ligand (methotrexate) is determined using inelastic neutron scattering. The vibrations of the complex soften significantly relative to the unbound protein. The resulting free-energy change, which is directly determined by the density of states change, is found to contribute significantly to the binding equilibrium

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