Giant Acceleration of DNA Diffusion in an Array of Entropic Barriers | Zendy

Daniel Kim | Zendy; Clark Bowman | Zendy; Jackson Travis Del Bonis-O’Donnell | Zendy; Anastasios Matzavinos | Zendy; Derek Stein | Zendy

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Giant Acceleration of DNA Diffusion in an Array of Entropic Barriers

Author(s) -

Daniel Kim,

Clark Bowman,

Jackson Travis Del Bonis-O’Donnell,

Anastasios Matzavinos,

Derek Stein

Publication year - 2017

Publication title -

physical review letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.688

H-Index - 673

eISSN - 1079-7114

pISSN - 0031-9007

DOI - 10.1103/physrevlett.118.048002

Subject(s) - acceleration , thermal diffusivity , diffusion , non equilibrium thermodynamics , polymer , chemical physics , flow (mathematics) , materials science , entropic force , statistical physics , thermodynamics , physics , mechanics , classical mechanics , composite material

We investigate with experiments and computer simulations the nonequilibrium dynamics of DNA polymers crossing arrays of entropic barriers in nanofluidic devices in a pressure-driven flow. With increasing driving pressure, the effective diffusivity of DNA rises and then peaks at a value that is many times higher than the equilibrium diffusivity. This is an entropic manifestation of "giant acceleration of diffusion." The phenomenon is sensitive to the effective energy landscape; thus, it offers a unique probe of entropic barriers in a system driven away from equilibrium.

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