Directed Motion of Proteins along Tethered Polyelectrolytes | Zendy

Katja Henzler | Zendy; Sabine Rosenfeldt | Zendy; Alexander Wittemann | Zendy; Ludger Harnau | Zendy; Stéphanie Finet | Zendy; Theyencheri Narayanan | Zendy; Matthias Ballauff | Zendy

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Directed Motion of Proteins along Tethered Polyelectrolytes

Author(s) -

Katja Henzler,

Sabine Rosenfeldt,

Alexander Wittemann,

Ludger Harnau,

Stéphanie Finet,

Theyencheri Narayanan,

Matthias Ballauff

Publication year - 2008

Publication title -

physical review letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.688

H-Index - 673

eISSN - 1079-7114

pISSN - 0031-9007

DOI - 10.1103/physrevlett.100.158301

Subject(s) - polyelectrolyte , motion (physics) , biophysics , chemical physics , materials science , physics , nuclear magnetic resonance , classical mechanics , polymer , biology

We present the first time-resolved investigation of motions of proteins in densely grafted layers of spherical polyelectrolyte brushes. Using small-angle x-ray scattering combined with rapid stopped-flow mixing, we followed the uptake of bovine serum albumin by poly(acrylic acid) layer with high spatial and temporal resolution. We find that the total amount of adsorbed protein scales with time as t(1/4). This subdiffusive behavior is explained on the basis of directed motion of the protein along the polyelectrolyte chains.

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