Open AccessHomologous Recombination and Replication Fork Protection: BRCA2 and More!
Author(s) -
Weiran Feng,
Maria Jasin
Publication year - 2017
Publication title -
cold spring harbor symposia on quantitative biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.615
H-Index - 77
eISSN - 1943-4456
pISSN - 0091-7451
DOI - 10.1101/sqb.2017.82.035006
Subject(s) - homologous recombination , genome instability , context (archaeology) , biology , dna replication , dna repair , homologous chromosome , fork (system call) , replication (statistics) , genetics , microbiology and biotechnology , computational biology , dna , dna damage , gene , computer science , virology , paleontology , operating system
BRCA2 is a breast and ovarian tumor suppressor that guards against genome instability, a hallmark of cancer. Significant progress has been made in improving our understanding of BRCA2 function from biochemical, cellular, and mouse studies. The knowledge gained has been actively exploited to develop therapeutic strategies, including PARP inhibition, which has shown promising clinical outcomes. Recently, tremendous excitement has been generated by the findings of the roles of BRCA2 and other proteins in suppressing replication stress through homologous recombination and in the protection of stalled replication forks. Processes such as mitotic DNA synthesis and fork reversal have taken center stage in these studies. Here, we discuss our recent findings in the context of these advances.
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