The Molecular Choreography of IRF4 and IRF8 with Immune System Partners | Zendy

Harinder Singh | Zendy; Elke Glasmacher | Zendy; Anne B. Chang | Zendy; Bryan Vander Lugt | Zendy

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The Molecular Choreography of IRF4 and IRF8 with Immune System Partners

Author(s) -

Harinder Singh,

Elke Glasmacher,

Anne B. Chang,

Bryan Vander Lugt

Publication year - 2013

Publication title -

cold spring harbor symposia on quantitative biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.615

H-Index - 77

eISSN - 1943-4456

pISSN - 0091-7451

DOI - 10.1101/sqb.2013.78.020305

Subject(s) - irf8 , irf4 , interferon regulatory factors , biology , transcription factor , gene , innate immune system , acquired immune system , interferon , immune system , ciita , gene duplication , regulation of gene expression , genetics , microbiology and biotechnology , immunology , major histocompatibility complex , mhc class ii

The transcription factors IRF4 and IRF8 represent immune-specific members of the interferon regulatory family. They play major roles in controlling the development and functioning of innate and adaptive cells. Genes encoding these factors appear to have been coopted by the immune system via gene duplication and divergence of regulatory and protein coding sequences to enable the acquisition of unique molecular properties and functions. Unlike other members of the IRF family, IRF4 and IRF8 do not activate transcription of Type 1 interferon genes or positively regulate interferon-induced gene expression. Instead, they bind to unusual composite Ets-IRF or AP-1-IRF elements with specific Ets or AP-1 family transcription factors, respectively, and regulate the expression of diverse sets of immune response genes in innate as well as adaptive cells.

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