TET Proteins and 5-Methylcytosine Oxidation in the Immune System | Zendy

Ageliki Tsagaratou | Zendy; Anjana Rao | Zendy

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TET Proteins and 5-Methylcytosine Oxidation in the Immune System

Author(s) -

Ageliki Tsagaratou,

Anjana Rao

Publication year - 2013

Publication title -

cold spring harbor symposia on quantitative biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.615

H-Index - 77

eISSN - 1943-4456

pISSN - 0091-7451

DOI - 10.1101/sqb.2013.78.020248

Subject(s) - dna demethylation , dna methylation , 5 methylcytosine , 5 hydroxymethylcytosine , epigenetics , biology , dna , methylation , demethylation , epigenomics , microbiology and biotechnology , computational biology , genetics , gene , gene expression

DNA methylation in the form of 5-methylcytosine (5mC) is essential for normal development in mammals and influences a variety of biological processes, including transcriptional regulation, imprinting, and the maintenance of genomic stability. The recent discovery of TET proteins, which oxidize 5mC to 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine, has changed our understanding of the process of DNA demethylation. Here, we summarize our current knowledge of the roles of DNA methylation and TET proteins in cell differentiation and function. The intensive research on this subject has so far focused primarily on embryonic stem (ES) cells and neurons. In addition, we summarize what is known about DNA methylation in T-cell function.

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