Transcription Factories and Nuclear Organization of the Genome | Zendy

Christopher H. Eskiw | Zendy; Nathan F. Cope | Zendy; Ieuan Clay | Zendy; Stefan Schoenfelder | Zendy; Takashi Nagano | Zendy; Peter Fraser | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Transcription Factories and Nuclear Organization of the Genome

Author(s) -

Christopher H. Eskiw,

Nathan F. Cope,

Ieuan Clay,

Stefan Schoenfelder,

Takashi Nagano,

Peter Fraser

Publication year - 2010

Publication title -

cold spring harbor symposia on quantitative biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.615

H-Index - 77

eISSN - 1943-4456

pISSN - 0091-7451

DOI - 10.1101/sqb.2010.75.046

Subject(s) - transcription factories , transcription (linguistics) , gene , biology , rna polymerase ii , nucleolus , genome , genetics , genomic organization , rna polymerase , rna , gene expression , promoter , microbiology and biotechnology , nucleus , linguistics , philosophy

The dynamic compartmental organization of the transcriptional machinery in mammalian nuclei places particular constraints on the spatial organization of the genome. The clustering of active RNA polymerase I transcription units from several chromosomes at nucleoli is probably the best-characterized and universally accepted example. RNA polymerase II localization in mammalian nuclei occurs in distinct concentrated foci that are several-fold fewer in number compared to the number of active genes and transcription units. Individual transcribed genes cluster at these shared transcription factories in a nonrandom manner, preferentially associating with heterologous, coregulated genes. We suggest that the three-dimensional (3D) conformation and relative arrangement of chromosomes in the nucleus has a major role in delivering tissue-specific gene-expression programs.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research