Role of the Nuclear Lamina in Genome Organization and Gene Expression | Zendy

Daan PericHupkes | Zendy; Bas van Steensel | Zendy

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Role of the Nuclear Lamina in Genome Organization and Gene Expression

Author(s) -

Daan PericHupkes,

Bas van Steensel

Publication year - 2010

Publication title -

cold spring harbor symposia on quantitative biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.615

H-Index - 77

eISSN - 1943-4456

pISSN - 0091-7451

DOI - 10.1101/sqb.2010.75.014

Subject(s) - nuclear lamina , biology , genome , gene , interphase , lamina , nuclear matrix , nuclear gene , gene expression , regulation of gene expression , microbiology and biotechnology , computational biology , genetics , evolutionary biology , nuclear protein , transcription factor , chromatin , anatomy

The nuclear lamina is a major structural component of metazoan nuclei that has long been thought to provide an anchoring site for interphase chromosomes and have a role in gene regulation. Recent genome-wide mapping studies and functional experimental data strongly support these roles of the nuclear lamina. Here, we discuss new insights into various aspects of genome-nuclear lamina interactions, with emphasis on the links with gene regulation and with dynamics during cellular differentiation.

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