Fine Mapping a Locus Controlling Leg Morphology in the Domestic Dog | Zendy

Pascale Quig | Zendy; Jeffrey J. Schoenebeck | Zendy; Kevin Chase | Zendy; Heidi G. Parker | Zendy; Dana S. Mosher | Zendy; Gary S. Johnson | Zendy; Karl G. Lark | Zendy; Elaine A. Ostrander | Zendy

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Fine Mapping a Locus Controlling Leg Morphology in the Domestic Dog

Author(s) -

Pascale Quig,

Jeffrey J. Schoenebeck,

Kevin Chase,

Heidi G. Parker,

Dana S. Mosher,

Gary S. Johnson,

Karl G. Lark,

Elaine A. Ostrander

Publication year - 2009

Publication title -

cold spring harbor symposia on quantitative biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.615

H-Index - 77

eISSN - 1943-4456

pISSN - 0091-7451

DOI - 10.1101/sqb.2009.74.009

Subject(s) - locus (genetics) , phenotype , genetics , biology , haplotype , single nucleotide polymorphism , genotyping , gene , allele , evolutionary biology , genotype

The domestic dog offers a remarkable opportunity to disentangle the genetics of complex phenotypes. Here, we explore a locus, previously identified in the Portuguese water dog (PWD), associated with PC2, a morphological principal component characterized as leg width versus leg length. The locus was initially mapped to a region of 26 Mb on canine chromosome 12 (CFA12) following a genome-wide scan. Subsequent and extensive genotyping of single-nucleotide polymorphisms (SNPs) and haplotype analysis in both the PWD and selected breeds representing phenotypic extremes of PC2 reduced the region from 26 Mb to 500 kb. The proximity of the critical interval to two collagen genes suggests that the phenotype may be controlled by cis-acting mechanisms.

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