How Does RNA Editing Affect dsRNA-mediated Gene Silencing? | Zendy

Brenda Bass | Zendy

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How Does RNA Editing Affect dsRNA-mediated Gene Silencing?

Author(s) -

Brenda Bass

Publication year - 2006

Publication title -

cold spring harbor symposia on quantitative biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.615

H-Index - 77

eISSN - 1943-4456

pISSN - 0091-7451

DOI - 10.1101/sqb.2006.71.037

Subject(s) - rna silencing , adar , rna editing , gene silencing , rna , rna interference , biology , rna induced silencing complex , rna induced transcriptional silencing , trans acting sirna , microbiology and biotechnology , rna binding protein , genetics , gene

In general, double-stranded RNA (dsRNA)-binding proteins (dsRBPs) are not sequence-specific. A dsRNA molecule in a cell will interact with any dsRBP it comes in contact with, suggesting that different dsRNA-mediated pathways intersect and affect each other. This paper analyzes evidence that the ADAR RNA editing enzymes, which act on dsRNA, affect dsRNA-mediated gene silencing pathways. Examples of how ADARs alter gene silencing pathways such as RNA interference, as well as mechanisms that allow the pathways to coexist and maintain their unique functions, are discussed.

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