MicroRNAs and Hematopoietic Differentiation | Zendy

Alessandro Fatica | Zendy; Alessandro Rosa | Zendy; Francesco Fazi | Zendy; Monica Ballarino | Zendy; Mariangela Morlando | Zendy; Fernanda Gabriella De Angelis | Zendy; Elisa Caffarelli | Zendy; Clara Nervi | Zendy; Irene Bozzoni | Zendy

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MicroRNAs and Hematopoietic Differentiation

Author(s) -

Alessandro Fatica,

Alessandro Rosa,

Francesco Fazi,

Monica Ballarino,

Mariangela Morlando,

Fernanda Gabriella De Angelis,

Elisa Caffarelli,

Clara Nervi,

Irene Bozzoni

Publication year - 2006

Publication title -

cold spring harbor symposia on quantitative biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.615

H-Index - 77

eISSN - 1943-4456

pISSN - 0091-7451

DOI - 10.1101/sqb.2006.71.014

Subject(s) - microrna , haematopoiesis , biology , lineage (genetic) , cellular differentiation , computational biology , mechanism (biology) , regulation of gene expression , gene , gene expression , microbiology and biotechnology , genetics , stem cell , philosophy , epistemology

The discovery of microRNAS (miRNAs) and of their mechanism of action has provided some very new clues on how gene expression is regulated. These studies established new concepts on how posttranscriptional control can fine-tune gene expression during differentiation and allowed the identification of new regulatory circuitries as well as factors involved therein. Because of the wealth of information available about the transcriptional and cellular networks involved in hematopoietic differentiation, the hematopoietic system is ideal for studying cell lineage specification. An interesting interplay between miRNAs and lineage-specific transcriptional factors has been found, and this can help us to understand how terminal differentiation is accomplished.

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