Measuring the Basic Physiological Properties of Synapses | Zendy

Matthew A. XuFriedman | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Measuring the Basic Physiological Properties of Synapses

Author(s) -

Matthew A. XuFriedman

Publication year - 2017

Publication title -

cold spring harbor protocols

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.674

H-Index - 51

eISSN - 1940-3402

pISSN - 1559-6095

DOI - 10.1101/pdb.top089680

Subject(s) - neuroscience , synaptic vesicle , neurotransmitter , brain function , neurotransmitter systems , function (biology) , neurotransmitter agents , cognitive science , biology , psychology , vesicle , microbiology and biotechnology , central nervous system , dopamine , genetics , membrane

Studying synaptic physiology remains an important endeavor for understanding the mechanisms that underlie neurotransmitter release as well as synaptic development and refinement. It is also critical to understanding brain function. The basic conceptual framework for synaptic physiology was worked out by Katz and colleagues and has coalesced around three factors: the number of releasable vesicles ( N ), the probability of release ( P ), and quantal size ( Q ). Here, I discuss a few key experiments related to these quantities and how they are assessed.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research