Double dissociation of pharmacologically induced deficits in visual recognition and visual discrimination learning | Zendy

Janita Turchi | Zendy; Deanne M. Buffalari | Zendy; Mortimer Mishkin | Zendy

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Double dissociation of pharmacologically induced deficits in visual recognition and visual discrimination learning

Author(s) -

Janita Turchi,

Deanne M. Buffalari,

Mortimer Mishkin

Publication year - 2008

Publication title -

learning and memory

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 136

eISSN - 1549-5485

pISSN - 1072-0502

DOI - 10.1101/lm.966208

Subject(s) - haloperidol , scopolamine , psychology , neuroscience , dissociation (chemistry) , cholinergic , dopaminergic , scopolamine hydrobromide , differential effects , discrimination learning , audiology , developmental psychology , cognitive psychology , pharmacology , chemistry , dopamine , medicine , muscarinic acetylcholine receptor , receptor

Monkeys trained in either one-trial recognition at 8- to 10-min delays or multi-trial discrimination habits with 24-h intertrial intervals received systemic cholinergic and dopaminergic antagonists, scopolamine and haloperidol, respectively, in separate sessions. Recognition memory was impaired markedly by scopolamine but not at all by haloperidol, whereas habit formation was impaired markedly by haloperidol but only minimally by scopolamine. These differential drug effects point to differences in synaptic modification induced by the two neuromodulators that parallel the contrasting properties of the two types of learning, namely, fast acquisition but weak retention of memories versus slow acquisition but durable retention of habits.

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